Abstract Determining the optimal positive end-expiratory pressure (PEEP) in patients with acute click here respiratory distress syndrome remains an area of active investigation.Most trials individualizing PEEP optimize one physiologic parameter (e.g.
, driving pressure) by titrating PEEP while holding other ventilator settings constant.Optimal PEEP, however, may depend on the tidal volume, and changing the tidal volume with which a la rams crop top best PEEP trial is performed may lead to different best PEEP settings in the same patient.Trial registration ClinicalTrials.
gov, NCT02871102.Registered on 12 August 2016.